InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAMA1

Summary

InnateDB Protein

IDBP-619.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMA1

Protein Name

laminin, alpha 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000374309

InnateDB Gene

IDBG-617 (LAMA1)

Protein Structure

UniProt Annotation

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0043208	glycosphingolipid binding

Biological Process

GO:0002011	morphogenesis of an epithelial sheet
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007411	axon guidance
GO:0009888	tissue development
GO:0030155	regulation of cell adhesion
GO:0030198	extracellular matrix organization
GO:0030334	regulation of cell migration
GO:0031175	neuron projection development
GO:0045198	establishment of epithelial cell apical/basal polarity
GO:0045995	regulation of embryonic development
GO:0060041	retina development in camera-type eye
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060445	branching involved in salivary gland morphogenesis
GO:0061304	retinal blood vessel morphogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005606	laminin-1 complex
GO:0005608	laminin-3 complex
GO:0005615	extracellular space
GO:0005911	cell-cell junction
GO:0031012	extracellular matrix
GO:0043256	laminin complex

Protein Structure and Domains

PDB ID

InterPro

IPR000034 Laminin B type IV
IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR002049 EGF-like, laminin
IPR008211 Laminin, N-terminal
IPR008979 Galactose-binding domain-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009254 Laminin I
IPR010307 Laminin domain II
IPR018031 Laminin B, subgroup

PFAM