Version 5.4
Homo sapiens Protein: TCL1A
Summary
InnateDB Protein IDBP-602402.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCL1A
Protein Name T-cell leukemia/lymphoma 1A
Synonyms TCL1;
Species Homo sapiens
Ensembl Protein ENSP00000450496
InnateDB Gene IDBG-18937 (TCL1A)
Protein Structure
UniProt Annotation
Function Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. {ECO:0000269PubMed:10716693, ECO:0000269PubMed:10983986, ECO:0000269PubMed:11707444, ECO:0000269PubMed:11839817}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Microsome {ECO:0000269PubMed:7987816}. Endoplasmic reticulum {ECO:0000269PubMed:7987816}. Note=Microsomal fraction.
Disease Associations Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
Tissue Specificity Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
Cellular Component
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID
InterPro IPR004832 TCL1/MTCP1
PFAM PF01840
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P56279
PhosphoSite PhosphoSite-P56279
TrEMBL A0A024R6G5
UniProt Splice Variant
Entrez Gene 8115
UniGene
RefSeq
HUGO HGNC:11648
OMIM 186960
CCDS CCDS9941
HPRD 01744
IMGT
EMBL BC003574 BC005831 BC014024 CH471061 CR456796 X82240
GenPept AAH03574 AAH05831 AAH14024 CAA57708 CAG33077 EAW81622 EAW81623

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca