Version 5.4
Homo sapiens Protein: CLSTN3
Summary
InnateDB Protein IDBP-602216.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLSTN3
Protein Name calsyntenin 3
Synonyms alcbeta; CDHR14; CSTN3;
Species Homo sapiens
Ensembl Protein ENSP00000440679
InnateDB Gene IDBG-16056 (CLSTN3)
Protein Structure
UniProt Annotation
Function May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. Golgi apparatus membrane. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. {ECO:0000250}.
Disease Associations
Tissue Specificity According to PubMed:12498782, expressed predominantly in the brain and in kidney. Low levels in heart, skeletal muscle, liver, placenta, pancreas and lung. According to PubMed:12972431, predominant expression in brain, and only marginal in kidney. In brain, present throughout all cortical layers, highest levels in GABAergic neurons (based on morphology and distribution pattern). {ECO:0000269PubMed:12498782, ECO:0000269PubMed:12972431}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002126 Cadherin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR015919 Cadherin-like
PFAM PF00028
PRINTS PR00205
PIRSF
SMART SM00112
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BQT9
PhosphoSite PhosphoSite-Q9BQT9
TrEMBL F5H7C7
UniProt Splice Variant
Entrez Gene 9746
UniGene Hs.535378
RefSeq XP_006719226
HUGO HGNC:18371
OMIM 611324
CCDS
HPRD 16725
IMGT
EMBL AB018269 AC018653 AJ277460 AY753302 BC104767 BC111491 BC112283 CH471116
GenPept AAI04768 AAI11492 AAI12284 AAV30552 BAA34446 CAC33084 EAW88677 EAW88678 EAW88679

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca