Version 5.4
Homo sapiens Protein: MEFV
Summary
InnateDB Protein IDBP-601353.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEFV
Protein Name Mediterranean fever
Synonyms FMF; MEF; TRIM20;
Species Homo sapiens
Ensembl Protein ENSP00000438711
InnateDB Gene IDBG-11729 (MEFV)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 18 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0008270 zinc ion binding
Biological Process
GO:0006954 inflammatory response
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032695 negative regulation of interleukin-12 production
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0050728 negative regulation of inflammatory response
GO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production
GO:2001056 positive regulation of cysteine-type endopeptidase activity
Cellular Component
GO:0001726 ruffle
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID
InterPro IPR000315 Zinc finger, B-box
IPR004020 DAPIN domain
IPR011029 Death-like domain
PFAM PF00643
PF02758
PRINTS
PIRSF
SMART SM00336
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15553
PhosphoSite PhosphoSite-O15553
TrEMBL I4DSV7
UniProt Splice Variant
Entrez Gene 4210
UniGene Hs.632221
RefSeq NP_001185465
HUGO HGNC:6998
OMIM 608107
CCDS CCDS55981
HPRD 02012
IMGT
EMBL AB726085 AF018080 AF111163 AF301150 AF301151 AJ003147 BC101511 BC101537 CH471112 Y14441
GenPept AAB70557 AAD26152 AAI01512 AAI01538 AAK97223 AAK97224 BAM20997 CAA05906 CAA74793 EAW85382 EAW85383

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca