Version 5.4
Homo sapiens Protein: PSME1
Summary
InnateDB Protein IDBP-599356.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSME1
Protein Name proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
Synonyms IFI5111; PA28A; PA28alpha; REGalpha;
Species Homo sapiens
Ensembl Protein ENSP00000453976
InnateDB Gene IDBG-3523 (PSME1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
Experimentally validated
Total 81 [view]
Protein-Protein 81 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0000278 mitotic cell cycle
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006521 regulation of cellular amino acid metabolic process
GO:0006915 apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0044281 small molecule metabolic process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Cellular Component
GO:0000502 proteasome complex
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008537 proteasome activator complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003185 Proteasome activator pa28, N-terminal domain
IPR003186 Proteasome activator pa28, C-terminal domain
IPR009077 Proteasome activator pa28
PFAM PF02251
PF02252
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q06323
PhosphoSite PhosphoSite-Q06323
TrEMBL
UniProt Splice Variant
Entrez Gene 5720
UniGene
RefSeq NP_001268457
HUGO HGNC:9568
OMIM 600654
CCDS CCDS61415
HPRD 02803
IMGT
EMBL AB007137 AF078829 AK312211 AL136295 BC000352 BC007503 BT019337 CH471078 CR456780 L07633 U10360
GenPept AAA16521 AAA53230 AAF02217 AAH00352 AAH07503 AAV38144 BAA28836 BAG35144 CAG33061 EAW66105

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca