Version 5.4
Homo sapiens Protein: POLN
Summary
InnateDB Protein IDBP-599007.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLN
Protein Name polymerase (DNA directed) nu
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000435506
InnateDB Gene IDBG-7355 (POLN)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Nucleus {ECO:0000269PubMed:12794064}.
Disease Associations
Tissue Specificity Highly expressed in testis and heart. Weakly expressed in skeletal muscle. {ECO:0000269PubMed:12794064}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0030332 cyclin binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0019985 translesion synthesis
GO:0036297 interstrand cross-link repair
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001098 DNA-directed DNA polymerase, family A, palm domain
IPR002298 DNA polymerase A
IPR012337 Ribonuclease H-like domain
PFAM PF00476
PRINTS PR00868
PIRSF
SMART SM00482
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z5Q5
PhosphoSite PhosphoSite-Q7Z5Q5
TrEMBL
UniProt Splice Variant
Entrez Gene 353497
UniGene Hs.739772
RefSeq
HUGO HGNC:18870
OMIM 610887
CCDS CCDS3360
HPRD 17876
IMGT
EMBL AK131239 AK303673 AL136360 AL158068 AY136549 CH471131 DQ060036
GenPept AAN52116 AAY43130 BAD18421 BAG64670 CAM16854 CAM20461 EAW82539

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca