InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNRNPC

Summary

InnateDB Protein

IDBP-597528.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPC

Protein Name

heterogeneous nuclear ribonucleoprotein C (C1/C2)

Synonyms

C1; C2; HNRNP; HNRPC; SNRPC;

Species

Homo sapiens

Ensembl Protein

ENSP00000451291

InnateDB Gene

IDBG-2589 (HNRNPC)

Protein Structure

UniProt Annotation

Function

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. {ECO:0000269PubMed:12509468, ECO:0000269PubMed:16010978, ECO:0000269PubMed:7567451, ECO:0000269PubMed:8264621}.

Subcellular Localization

Nucleus. Note=Component of ribonucleosomes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 173 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	173 [view]
Protein-Protein	169 [view]
Protein-DNA	1 [view]
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0008266	poly(U) RNA binding
GO:0031492	nucleosomal DNA binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0001649	osteoblast differentiation
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043044	ATP-dependent chromatin remodeling
GO:0070935	3'-UTR-mediated mRNA stabilization

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005829	cytosol
GO:0016020	membrane
GO:0043234	protein complex
GO:0045120	pronucleus
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR016137 Regulator of G protein signalling superfamily
IPR017347 Heterogeneous nuclear ribonucleoprotein C, Raly

PFAM

PF00076

PRINTS

PIRSF

PIRSF037992

SMART

SM00360
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt