InnateDB Protein
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IDBP-596042.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SMEK1
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Protein Name
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SMEK homolog 1, suppressor of mek1 (Dictyostelium)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000450891
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InnateDB Gene
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IDBG-16359 (SMEK1)
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Protein Structure
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Function |
Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269PubMed:18614045}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:18487071}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:18487071}. Nucleus {ECO:0000269PubMed:18487071}. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
27
[view]
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Protein-Protein |
27
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006887
Domain of unknown function DUF625
IPR016024
Armadillo-type fold
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PFAM |
PF04802
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6IN85
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PhosphoSite |
PhosphoSite-Q6IN85
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TrEMBL |
G3V5A2
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UniProt Splice Variant |
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Entrez Gene |
55671
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UniGene |
Hs.733508
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RefSeq |
NP_001271210
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HUGO |
HGNC:20219
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OMIM |
610351
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CCDS |
CCDS61532
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HPRD |
11176
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IMGT |
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EMBL |
AB095930
AF113213
AK000714
AK001885
AK024297
AL133153
AL832921
BC038932
BC072409
BX248247
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GenPept |
AAG39284
AAH38932
AAH72409
BAA91338
BAA91960
BAB14877
BAC23106
CAD62575
CAH10634
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