InnateDB Protein
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IDBP-594136.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HNRNPC
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Protein Name
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heterogeneous nuclear ribonucleoprotein C (C1/C2)
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Synonyms
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C1; C2; HNRNP; HNRPC; SNRPC;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000451652
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InnateDB Gene
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IDBG-2589 (HNRNPC)
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Protein Structure
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Function |
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. {ECO:0000269PubMed:12509468, ECO:0000269PubMed:16010978, ECO:0000269PubMed:7567451, ECO:0000269PubMed:8264621}.
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Subcellular Localization |
Nucleus. Note=Component of ribonucleosomes.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 173 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
173
[view]
|
Protein-Protein |
169
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
3
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR016137
Regulator of G protein signalling superfamily
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00315
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TIGRFAMs |
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Modification |
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SwissProt |
P07910
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PhosphoSite |
PhosphoSite-P07910
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
3183
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UniGene |
Hs.735530
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RefSeq |
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HUGO |
HGNC:5035
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OMIM |
164020
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CCDS |
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HPRD |
01243
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IMGT |
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EMBL |
AB209527
AK223517
BC003394
BC007052
BC008364
BC008423
BC066932
BC089438
BC103758
BC108658
BX161480
BX247961
BX247992
CH471078
M16342
M29063
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GenPept |
AAA36576
AAA52680
AAH03394
AAH07052
AAH08364
AAH08423
AAH66932
AAH89438
AAI03759
AAI08659
BAD92764
BAD97237
CAD61934
CAD62300
CAD62326
EAW66392
EAW66393
EAW66394
EAW66395
EAW66396
EAW66399
EAW66400
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