InnateDB Protein
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IDBP-591661.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RBM25
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Protein Name
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RNA binding motif protein 25
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000434444
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InnateDB Gene
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IDBG-11203 (RBM25)
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Protein Structure
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Function |
RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269PubMed:18663000, ECO:0000269PubMed:21859973}.
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Subcellular Localization |
Nucleus speckle. Cytoplasm. Note=Colocalizes predominantly, with SFRS2 and LUC7L3 splicing factors, in nuclear speckles. Cytoplasmic localization is faint.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
53
[view]
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Protein-Protein |
52
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P49756
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PhosphoSite |
PhosphoSite-P49756
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
58517
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UniGene |
Hs.607781
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RefSeq |
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HUGO |
HGNC:23244
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OMIM |
612427
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CCDS |
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HPRD |
15229
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IMGT |
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EMBL |
AC004858
AF109907
AK026107
AK094697
AL442663
BC062440
BC083496
BC111066
BC113389
BC113391
BC136775
BC136776
BC144407
CH471061
L40392
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GenPept |
AAC41999
AAC97961
AAF19255
AAH62440
AAH83496
AAI11067
AAI13390
AAI13392
AAI36776
AAI36777
AAI44408
BAB15362
BAG52915
EAW81087
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