InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NLRP1

Summary

InnateDB Protein

IDBP-589916.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLRP1

Protein Name

NLR family, pyrin domain containing 1

Synonyms

CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; NAC; NALP1; PP1044; SLEV1; VAMAS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000442029

InnateDB Gene

IDBG-21836 (NLRP1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0032495	response to muramyl dipeptide
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050727	regulation of inflammatory response
GO:0051402	neuron apoptotic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005829	cytosol
GO:0072558	NLRP1 inflammasome complex

Protein Structure and Domains

PDB ID

InterPro

IPR001611 Leucine-rich repeat
IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR004020 DAPIN domain
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00560
PF13504
PF13855
PF02758

PRINTS

PIRSF

SMART

SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9C000