InnateDB Protein
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IDBP-5899.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ANGPT2
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Protein Name
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angiopoietin 2
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Synonyms
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AGPT2; ANG2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000343517
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InnateDB Gene
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IDBG-5893 (ANGPT2)
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Protein Structure
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Function |
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. {ECO:0000269PubMed:15284220, ECO:0000269PubMed:19116766, ECO:0000269PubMed:19223473, ECO:0000269PubMed:9204896}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002181
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
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PFAM |
PF00147
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PRINTS |
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PIRSF |
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SMART |
SM00186
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TIGRFAMs |
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Modification |
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SwissProt |
O15123
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PhosphoSite |
PhosphoSite-O15123
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TrEMBL |
Q9HBP3
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UniProt Splice Variant |
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Entrez Gene |
285
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UniGene |
Hs.583870
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RefSeq |
NP_001112360
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HUGO |
HGNC:485
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OMIM |
601922
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CCDS |
CCDS47761
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HPRD |
03563
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IMGT |
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EMBL |
AB009865
AC018398
AF004327
AF187858
AF218015
AJ289781
AK290070
AY563557
BC126200
BC126202
BC143902
CH471153
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GenPept |
AAB63190
AAF76526
AAG17257
AAI26201
AAI26203
AAI43903
AAT69979
BAA95590
BAF82759
CAC08180
EAW80474
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