Version 5.4
Homo sapiens Protein: SMG6
Summary
InnateDB Protein IDBP-588555.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMG6
Protein Name smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Synonyms C17orf31; EST1A; hSMG5/7a; SMG-6;
Species Homo sapiens
Ensembl Protein ENSP00000440283
InnateDB Gene IDBG-16046 (SMG6)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004521 endoribonuclease activity
GO:0005515 protein binding
GO:0042162 telomeric DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000723 telomere maintenance
GO:0006406 mRNA export from nucleus
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0035303 regulation of dephosphorylation
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005697 telomerase holoenzyme complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0035145 exon-exon junction complex
Protein Structure and Domains
PDB ID
InterPro IPR002716 PIN domain
IPR029060 PIN domain-like
PFAM PF01850
PF10130
PF13470
PF13638
PRINTS
PIRSF
SMART SM00670
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86US8
PhosphoSite PhosphoSite-Q86US8
TrEMBL K7ENH7
UniProt Splice Variant
Entrez Gene 23293
UniGene Hs.448342
RefSeq NP_001269255
HUGO HGNC:17809
OMIM 610963
CCDS CCDS58498
HPRD 06502
IMGT
EMBL AB018275 AC090617 AK302964 AL133597 AL450226 AY145883 AY168921 BC064916 CH471108
GenPept AAH64916 AAN46114 AAO17581 BAA34452 BAH13860 CAB63733 EAW90559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca