Version 5.4
Homo sapiens Protein: SMEK1
Summary
InnateDB Protein IDBP-588324.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMEK1
Protein Name SMEK homolog 1, suppressor of mek1 (Dictyostelium)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000450864
InnateDB Gene IDBG-16359 (SMEK1)
Protein Structure
UniProt Annotation
Function Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269PubMed:18614045}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18487071}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:18487071}. Nucleus {ECO:0000269PubMed:18487071}. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0045722 positive regulation of gluconeogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0030289 protein phosphatase 4 complex
Protein Structure and Domains
PDB ID
InterPro IPR006887 Domain of unknown function DUF625
IPR016024 Armadillo-type fold
PFAM PF04802
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6IN85
PhosphoSite PhosphoSite-Q6IN85
TrEMBL G3V5Z3
UniProt Splice Variant
Entrez Gene 55671
UniGene Hs.733508
RefSeq NP_001271209
HUGO HGNC:20219
OMIM 610351
CCDS CCDS9895
HPRD 11176
IMGT
EMBL AB095930 AF113213 AK000714 AK001885 AK024297 AL133153 AL832921 BC038932 BC072409 BX248247 CH471061
GenPept AAG39284 AAH38932 AAH72409 BAA91338 BAA91960 BAB14877 BAC23106 CAD62575 CAH10634 EAW81452 EAW81455

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca