InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DICER1

Summary

InnateDB Protein

IDBP-586091.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DICER1

Protein Name

dicer 1, ribonuclease type III

Synonyms

DCR1; Dicer; Dicer1e; HERNA; MNG1; RMSE2;

Species

Homo sapiens

Ensembl Protein

ENSP00000451041

InnateDB Gene

IDBG-18522 (DICER1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	76 [view]
Protein-Protein	74 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0004386	helicase activity
GO:0004525	ribonuclease III activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006396	RNA processing
GO:0010467	gene expression
GO:0010626	negative regulation of Schwann cell proliferation
GO:0014040	positive regulation of Schwann cell differentiation
GO:0021675	nerve development
GO:0030422	production of siRNA involved in RNA interference
GO:0030423	targeting of mRNA for destruction involved in RNA interference
GO:0031054	pre-miRNA processing
GO:0031643	positive regulation of myelination
GO:0032290	peripheral nervous system myelin formation
GO:0035196	production of miRNAs involved in gene silencing by miRNA
GO:0045087	innate immune response (InnateDB)
GO:0048812	neuron projection morphogenesis
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic