InnateDB Protein
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IDBP-585106.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PSPC1
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Protein Name
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paraspeckle component 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000435921
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InnateDB Gene
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IDBG-12561 (PSPC1)
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Protein Structure
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Function |
Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles. {ECO:0000250, ECO:0000269PubMed:22416126}.
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Subcellular Localization |
Nucleus, nucleolus. Nucleus matrix {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus speckle. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycles between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps.
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Disease Associations |
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Tissue Specificity |
Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. {ECO:0000269PubMed:11790299}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR012975
NOPS
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PFAM |
PF00076
PF08075
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q8WXF1
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PhosphoSite |
PhosphoSite-Q8WXF1
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TrEMBL |
X6RDA4
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UniProt Splice Variant |
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Entrez Gene |
55269
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UniGene |
Hs.732043
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RefSeq |
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HUGO |
HGNC:20320
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OMIM |
612408
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CCDS |
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HPRD |
10172
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IMGT |
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EMBL |
AF448795
AF449627
AK001817
AL354808
AL834505
BC014184
CH471075
CR457272
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GenPept |
AAH14184
AAL59601
AAL59602
BAA91924
CAD39162
CAG33553
CAI41004
CAI41005
EAX08232
EAX08233
EAX08234
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