Version 5.4
Homo sapiens Protein: APBA2
Summary
InnateDB Protein IDBP-583314.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APBA2
Protein Name amyloid beta (A4) precursor protein-binding, family A, member 2
Synonyms D15S1518E; HsT16821; LIN-10; MGC:14091; MINT2; X11-BETA; X11L;
Species Homo sapiens
Ensembl Protein ENSP00000453144
InnateDB Gene IDBG-4634 (APBA2)
Protein Structure
UniProt Annotation
Function Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
Subcellular Localization
Disease Associations
Tissue Specificity Brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007399 nervous system development
GO:0015031 protein transport
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
IPR006020 PTB/PI domain
PFAM PF00595
PF13180
PF00640
PF14719
PRINTS
PIRSF
SMART SM00228
SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99767
PhosphoSite PhosphoSite-Q99767
TrEMBL H0YNG7
UniProt Splice Variant
Entrez Gene 321
UniGene Hs.721380
RefSeq
HUGO HGNC:579
OMIM 602712
CCDS CCDS10022
HPRD 04090
IMGT
EMBL AB014719 AC024474 AC127522 AC174469 AF029108 AF047348 BC082986 U79255
GenPept AAB50203 AAC05306 AAC39767 AAH82986 BAA34734

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca