InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lgals3

Summary

InnateDB Protein

IDBP-533749.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lgals3

Protein Name

lectin, galactose binding, soluble 3

Synonyms

gal3; GBP; L-34; Mac-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114350

InnateDB Gene

IDBG-154384 (Lgals3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019863	IgE binding
GO:0030246	carbohydrate binding
GO:0042056	chemoattractant activity
GO:0043236	laminin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001501	skeletal system development
GO:0002548	monocyte chemotaxis
GO:0030198	extracellular matrix organization
GO:0030593	neutrophil chemotaxis
GO:0030855	epithelial cell differentiation
GO:0042129	regulation of T cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045806	negative regulation of endocytosis
GO:0048245	eosinophil chemotaxis
GO:0048246	macrophage chemotaxis
GO:0050918	positive chemotaxis
GO:0070232	regulation of T cell apoptotic process
GO:0071674	mononuclear cell migration
GO:0071677	positive regulation of mononuclear cell migration
GO:0090280	positive regulation of calcium ion import
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005743	mitochondrial inner membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome