InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myo5a

Summary

InnateDB Protein

IDBP-532111.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo5a

Protein Name

myosin VA

Synonyms

9630007J19Rik; AI413174; AI661011; d; d-120J; Dbv; flail; flr; MVa; Myo5; MyoVA; Sev-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116028

InnateDB Gene

IDBG-184743 (Myo5a)

Protein Structure

UniProt Annotation

Function

Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation. {ECO:0000269PubMed:22908308}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in melanocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0017137	Rab GTPase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006582	melanin metabolic process
GO:0006887	exocytosis
GO:0007268	synaptic transmission
GO:0007601	visual perception
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0030048	actin filament-based movement
GO:0030050	vesicle transport along actin filament
GO:0030073	insulin secretion
GO:0030318	melanocyte differentiation
GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0031987	locomotion involved in locomotory behavior
GO:0032252	secretory granule localization
GO:0032400	melanosome localization
GO:0032402	melanosome transport
GO:0032869	cellular response to insulin stimulus
GO:0042438	melanin biosynthetic process
GO:0042476	odontogenesis
GO:0042552	myelination
GO:0042640	anagen
GO:0042759	long-chain fatty acid biosynthetic process
GO:0043473	pigmentation
GO:0048066	developmental pigmentation
GO:0050808	synapse organization
GO:0051643	endoplasmic reticulum localization
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0001726	ruffle
GO:0001750	photoreceptor outer segment
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005882	intermediate filament
GO:0016020	membrane
GO:0016459	myosin complex
GO:0030141	secretory granule
GO:0032593	insulin-responsive compartment
GO:0035371	microtubule plus-end
GO:0042470	melanosome
GO:0042641	actomyosin
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:105976

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR002710 Dilute
IPR016072 SKP1 component, dimerisation
IPR018444 Dil domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF01466
PF01843

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt