InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C22orf28

Summary

InnateDB Protein

IDBP-5112.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C22orf28

Protein Name

chromosome 22 open reading frame 28

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000216038

InnateDB Gene

IDBG-5110 (C22orf28)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'- phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. {ECO:0000269PubMed:21311021, ECO:0000269PubMed:24870230}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:24608264}. Cytoplasm {ECO:0000255HAMAP-Rule:MF_03144, ECO:0000269PubMed:24608264}. Note=Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low. {ECO:0000269PubMed:24608264}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	49 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003972	RNA ligase (ATP) activity
GO:0005524	ATP binding
GO:0008452	RNA ligase activity
GO:0017166	vinculin binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001890	placenta development
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006396	RNA processing