InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC5A1

Summary

InnateDB Protein

IDBP-4966.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC5A1

Protein Name

solute carrier family 5 (sodium/glucose cotransporter), member 1

Synonyms

D22S675; NAGT; SGLT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000266088

InnateDB Gene

IDBG-4964 (SLC5A1)

Protein Structure

UniProt Annotation

Function

Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Congenital glucose/galactose malabsorption (GGM) [MIM:606824]: Intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet. {ECO:0000269PubMed:10036327, ECO:0000269PubMed:11406349, ECO:0000269PubMed:2008213, ECO:0000269PubMed:8195156}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed mainly in intestine and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005355	glucose transmembrane transporter activity
GO:0005412	glucose:sodium symporter activity
GO:0005515	protein binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006810	transport
GO:0006814	sodium ion transport
GO:0008645	hexose transport
GO:0015758	glucose transport
GO:0044281	small molecule metabolic process
GO:0050892	intestinal absorption
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005903	brush border
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0070062	extracellular vesicular exosome