InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YWHAH

Summary

InnateDB Protein

IDBP-4949.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YWHAH

Protein Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

Synonyms

YWHA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000248975

InnateDB Gene

IDBG-4947 (YWHAH)

Protein Structure

UniProt Annotation

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269PubMed:12177059}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed mainly in the brain and present in other tissues albeit at lower levels.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 212 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	212 [view]
Protein-Protein	206 [view]
Protein-DNA	5 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0035259	glucocorticoid receptor binding
GO:0044325	ion channel binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002028	regulation of sodium ion transport
GO:0006713	glucocorticoid catabolic process
GO:0006886	intracellular protein transport
GO:0006915	apoptotic process
GO:0021762	substantia nigra development
GO:0042921	glucocorticoid receptor signaling pathway
GO:0045664	regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048167	regulation of synaptic plasticity
GO:0050774	negative regulation of dendrite morphogenesis
GO:0061024	membrane organization
GO:0086010	membrane depolarization during action potential
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000649	regulation of sodium ion transmembrane transporter activity

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0014704	intercalated disc
GO:0030659	cytoplasmic vesicle membrane
GO:0070062	extracellular vesicular exosome