InnateDB Protein
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IDBP-482108.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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WIPI2
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Protein Name
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WD repeat domain, phosphoinositide interacting 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000429654
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InnateDB Gene
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IDBG-7422 (WIPI2)
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Protein Structure
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Function |
Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P. {ECO:0000269PubMed:20505359}.
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Subcellular Localization |
Preautophagosomal structure membrane {ECO:0000269PubMed:20505359, ECO:0000269PubMed:21564513, ECO:0000269PubMed:22456507}; Peripheral membrane protein {ECO:0000269PubMed:20505359, ECO:0000269PubMed:21564513, ECO:0000269PubMed:22456507}; Cytoplasmic side {ECO:0000269PubMed:20505359, ECO:0000269PubMed:21564513, ECO:0000269PubMed:22456507}. Note=Enriched at preautophagosomal structure membranes in response to ptdIns3P.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. {ECO:0000269PubMed:15602573, ECO:0000269PubMed:20505359}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0032266
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phosphatidylinositol-3-phosphate binding
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GO:0080025
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phosphatidylinositol-3,5-bisphosphate binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
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PFAM |
PF00400
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PRINTS |
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y4P8
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PhosphoSite |
PhosphoSite-Q9Y4P8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26100
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UniGene |
Hs.700671
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RefSeq |
NP_001265228
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HUGO |
HGNC:32225
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OMIM |
609225
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CCDS |
CCDS47533
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HPRD |
15679
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IMGT |
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EMBL |
AC093376
AF151808
AK024279
AL080155
AY691425
AY691426
BC004116
BC007596
BC021068
BC021200
CH471144
CR533530
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GenPept |
AAD34045
AAH04116
AAH07596
AAH21200
AAQ96865
AAQ96866
AAQ96867
AAV80761
AAV80762
BAG51284
CAB45746
CAG38561
EAW87328
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