Version 5.4
Homo sapiens Protein: FIP1L1
Summary
InnateDB Protein IDBP-481350.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FIP1L1
Protein Name FIP1 like 1 (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000425456
InnateDB Gene IDBG-18445 (FIP1L1)
Protein Structure
UniProt Annotation
Function Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269PubMed:14749727}.
Subcellular Localization Nucleus.
Disease Associations Note=A chromosomal aberration involving FIP1L1 is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA). {ECO:0000269PubMed:12660384, ECO:0000269PubMed:12808148}.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007854 Pre-mRNA polyadenylation factor Fip1
PFAM PF05182
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UN15
PhosphoSite PhosphoSite-Q6UN15
TrEMBL
UniProt Splice Variant
Entrez Gene 81608
UniGene Hs.624245
RefSeq
HUGO HGNC:19124
OMIM 607686
CCDS
HPRD 09646
IMGT
EMBL AC058822 AC095040 AC098587 AC098821 AC105384 AC110298 AC110792 AC124017 AC138607 AC138779 AK295737 AL136910 AY229892 AY366510 BC011543 BC017724 BC024016 BC052959 BC110383 CH471057
GenPept AAH11543 AAH17724 AAH24016 AAH52959 AAI10384 AAP69563 AAQ88277 BAG58575 CAB66844 EAX05448

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca