Homo sapiens Protein: MCM4 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-481343.4 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | MCM4 | ||||||||||||||||||||||
Protein Name | minichromosome maintenance complex component 4 | ||||||||||||||||||||||
Synonyms | CDC21; CDC54; hCdc21; NKCD; NKGCD; P1-CDC21; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000430194 | ||||||||||||||||||||||
InnateDB Gene | IDBG-21089 (MCM4) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. {ECO:0000269PubMed:9305914}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | Natural killer cell and glucocorticoid deficiency with DNA repair defect (NKGCD) [MIM:609981]: An autosomal recessive disorder characterized by severe intra- and extrauterine growth retardation, microcephaly, decreased numbers of natural killer cells, and recurrent viral infections, most often affecting the respiratory tract and leading to respiratory failure. Affected individuals also have adrenal insufficiency requiring corticosteroid replacement therapy and may have an increased susceptibility to cancer. {ECO:0000269PubMed:22354167, ECO:0000269PubMed:22354170, ECO:0000269PubMed:22499342}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000523
Magnesium chelatase, ChlI subunit IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase IPR008047 Mini-chromosome maintenance complex protein 4 IPR011703 ATPase, AAA-3 IPR011704 ATPase, dynein-related, AAA domain IPR012340 Nucleic acid-binding, OB-fold IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF01078
PF00493 PF07726 PF07728 |
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PRINTS |
PR01657
PR01660 |
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PIRSF | |||||||||||||||||||||||
SMART |
SM00350
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P33991 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P33991 | ||||||||||||||||||||||
TrEMBL | E5RFR3 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 4173 | ||||||||||||||||||||||
UniGene | Hs.629265 | ||||||||||||||||||||||
RefSeq | NP_877423 | ||||||||||||||||||||||
HUGO | HGNC:6947 | ||||||||||||||||||||||
OMIM | 602638 | ||||||||||||||||||||||
CCDS | CCDS6143 | ||||||||||||||||||||||
HPRD | 09094 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC021236 AM493756 AY588245 BC031061 U63630 U90415 X74794 | ||||||||||||||||||||||
GenPept | AAB51723 AAC52018 AAH31061 AAS83108 CAA52801 CAM35476 | ||||||||||||||||||||||