InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAM18

Summary

InnateDB Protein

IDBP-479576.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAM18

Protein Name

ADAM metallopeptidase domain 18

Synonyms

ADAM27; tMDCIII;

Species

Homo sapiens

Ensembl Protein

ENSP00000429908

InnateDB Gene

IDBG-18575 (ADAM18)

Protein Structure

UniProt Annotation

Function

Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed specifically in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002870 Peptidase M12B, propeptide

PFAM

PF01562

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y3Q7

PhosphoSite

PhosphoSite-Q9Y3Q7

TrEMBL

E5RK96

UniProt Splice Variant

Entrez Gene

8749

UniGene

Hs.127930

RefSeq

NP_001177885

HUGO

HGNC:196

OMIM

CCDS

CCDS55225

HPRD

07469

IMGT

EMBL

AC109633 AC136365 AJ133004 AK313961 AY358321 BC034624 BC070279 BC121045

GenPept

AAH34624 AAH70279 AAI21046 AAQ88687 BAG36677 CAB40812