InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SDHA

Summary

InnateDB Protein

IDBP-478100.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SDHA

Protein Name

succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

Synonyms

CMD1GG; FP; PGL5; SDH1; SDH2; SDHF;

Species

Homo sapiens

Ensembl Protein

ENSP00000427703

InnateDB Gene

IDBG-10076 (SDHA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000104	succinate dehydrogenase activity
GO:0005515	protein binding
GO:0008177	succinate dehydrogenase (ubiquinone) activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006105	succinate metabolic process
GO:0007399	nervous system development
GO:0022900	electron transport chain
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005749	mitochondrial respiratory chain complex II

Protein Structure and Domains

PDB ID

InterPro

IPR003953 FAD binding domain
IPR011281 Succinate dehydrogenase, flavoprotein subunit
IPR014006 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain

PFAM

PF00890
PF02910
PF07992

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P31040

PhosphoSite