InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STIM2

Summary

InnateDB Protein

IDBP-477047.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STIM2

Protein Name

stromal interaction molecule 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000419073

InnateDB Gene

IDBG-12896 (STIM2)

Protein Structure

UniProt Annotation

Function

Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269PubMed:16005298, ECO:0000269PubMed:16860747, ECO:0000269PubMed:17905723, ECO:0000269PubMed:18160041, ECO:0000269PubMed:21217057, ECO:0000269PubMed:22464749, ECO:0000269PubMed:23359669}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:16860747, ECO:0000269PubMed:17905723, ECO:0000269PubMed:18160041}; Single-pass type I membrane protein {ECO:0000269PubMed:16860747, ECO:0000269PubMed:17905723, ECO:0000269PubMed:18160041}. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.

Disease Associations

Tissue Specificity

Expressed in all tissues and tumor cell lines examined. {ECO:0000269PubMed:11463338}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005246	calcium channel regulator activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0015279	store-operated calcium channel activity

Biological Process

GO:0006874	cellular calcium ion homeostasis
GO:0032237	activation of store-operated calcium channel activity
GO:0051928	positive regulation of calcium ion transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF07647
PF00536

PRINTS

PIRSF

SMART

SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9P246