InnateDB Protein
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IDBP-476344.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CD38
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Protein Name
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CD38 molecule
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Synonyms
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ADPRC 1; T10;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000427277
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InnateDB Gene
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IDBG-10668 (CD38)
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Protein Structure
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Function |
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
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Subcellular Localization |
Membrane; Single-pass type II membrane protein.
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Disease Associations |
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Tissue Specificity |
Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. {ECO:0000269PubMed:9074508}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
|
Protein-Protein |
9
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003193
ADP-ribosyl cyclase (CD38/157)
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PFAM |
PF02267
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P28907
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PhosphoSite |
PhosphoSite-P28907
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TrEMBL |
Q4FCX6
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UniProt Splice Variant |
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Entrez Gene |
952
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UniGene |
Hs.735022
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RefSeq |
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HUGO |
HGNC:1667
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OMIM |
107270
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CCDS |
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HPRD |
00116
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IMGT |
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EMBL |
BC007964
D84276
D84277
D84284
DQ091293
M34461
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GenPept |
AAA68482
AAH07964
AAY99634
BAA18964
BAA18965
BAA18966
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