InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DPYSL2

Summary

InnateDB Protein

IDBP-475865.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPYSL2

Protein Name

dihydropyrimidinase-like 2

Synonyms

CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3; ULIP-2; ULIP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000431117

InnateDB Gene

IDBG-13200 (DPYSL2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004157	dihydropyrimidinase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006208	pyrimidine nucleobase catabolic process
GO:0006897	endocytosis
GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0007411	axon guidance

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR006680 Amidohydrolase 1
IPR011059 Metal-dependent hydrolase, composite domain
IPR011778 Hydantoinase/dihydropyrimidinase

PFAM

PF01979

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-Q16555

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB020777 AC015564 AC015743 AK092377 AK291287 AK299077 BC056408 BC067109 CH471080 D78013 U17279 U97105

GenPept

AAA93202 AAC05793 AAH56408 AAH67109 BAA11191 BAA86991 BAC03872 BAF83976 BAG61143 EAW63573 EAW63574

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca