Version 5.4
Homo sapiens Protein: EIF4ENIF1
Summary
InnateDB Protein IDBP-4691.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4ENIF1
Protein Name eukaryotic translation initiation factor 4E nuclear import factor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000328103
InnateDB Gene IDBG-4689 (EIF4ENIF1)
Protein Structure
UniProt Annotation
Function Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:22090346}. Nucleus {ECO:0000269PubMed:22090346}. Nucleus, PML body {ECO:0000269PubMed:22090346}. Nucleus speckle {ECO:0000269PubMed:22090346}. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription.
Disease Associations
Tissue Specificity Widely expressed.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 21 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008565 protein transporter activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0015031 protein transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR018862 Eukaryotic translation initiation factor 4E transporter
PFAM PF10477
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRA8
PhosphoSite PhosphoSite-Q9NRA8
TrEMBL B1AKL6
UniProt Splice Variant
Entrez Gene 56478
UniGene Hs.517559
RefSeq NP_062817
HUGO HGNC:16687
OMIM 607445
CCDS CCDS13898
HPRD 10456
IMGT
EMBL AF240775 AK025254 AK074768 AK314636 AL096701 BC032941 BC033028 CH471095 CR456386
GenPept AAF81693 AAH32941 AAH33028 BAB15092 BAC11194 BAG37198 CAG30272 EAW59977 EAW59978 EAW59979

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca