InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BAZ1A

Summary

InnateDB Protein

IDBP-4609.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAZ1A

Protein Name

bromodomain adjacent to zinc finger domain, 1A

Synonyms

ACF1; hACF1; WALp1; WCRF180;

Species

Homo sapiens

Ensembl Protein

ENSP00000353458

InnateDB Gene

IDBG-4605 (BAZ1A)

Protein Structure

UniProt Annotation

Function

Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end- positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.Component of the histone-fold protein complex CHRAC complex which faciliates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions.

Subcellular Localization

Nucleus. Note=May target the CHRAC complex to heterochromatin.

Disease Associations

Tissue Specificity

Highly expressed in testis and at low or undetectable levels in other tissues analyzed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006261	DNA-dependent DNA replication
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0000228	nuclear chromosome
GO:0008623	CHRAC
GO:0016590	ACF complex

Protein Structure and Domains

PDB ID

InterPro

IPR001487 Bromodomain
IPR001965 Zinc finger, PHD-type
IPR004022 DDT domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR013136 WSTF/Acf1/Cbp146
IPR018500 DDT domain, subgroup
IPR018501 DDT domain superfamily
IPR019787 Zinc finger, PHD-finger

PFAM

PF00439
PF02791
PF10537
PF00628

PRINTS

PR00503

PIRSF

SMART

SM00297
SM00249
SM00571

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt