InnateDB Protein
|
IDBP-4492.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SERPINB3
|
Protein Name
|
serpin peptidase inhibitor, clade B (ovalbumin), member 3
|
Synonyms
|
HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1; T4-A;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000329498
|
InnateDB Gene
|
IDBG-4488 (SERPINB3)
|
Protein Structure
|
|
Function |
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). {ECO:0000269PubMed:19166818}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:10956412, ECO:0000269PubMed:14970861}. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.
|
Disease Associations |
|
Tissue Specificity |
Squamous cells. Expressed in some hepatocellular carcinoma (at protein level). {ECO:0000269PubMed:14970861}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
17
[view]
|
Protein-Protein |
17
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0001618
|
virus receptor activity
|
GO:0004867
|
serine-type endopeptidase inhibitor activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR023796
Serpin domain
|
PFAM |
PF00079
|
PRINTS |
|
PIRSF |
|
SMART |
SM00093
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P29508
|
PhosphoSite |
PhosphoSite-P29508
|
TrEMBL |
Q9BYH9
|
UniProt Splice Variant |
|
Entrez Gene |
6317
|
UniGene |
Hs.227948
|
RefSeq |
|
HUGO |
HGNC:10569
|
OMIM |
600517
|
CCDS |
|
HPRD |
02745
|
IMGT |
|
EMBL |
AB034984
AB046399
AC069356
AJ515706
AK222746
AK222753
AK314805
AY190327
AY245778
AY245781
BC005224
BT006748
CH471096
EU852041
S66896
U19556
U19559
U19560
U19562
U19565
U19567
U19568
|
GenPept |
AAA86316
AAA86317
AAA97552
AAB20405
AAH05224
AAO11731
AAO92269
AAO92272
AAP35394
ACF21012
BAB21524
BAB40772
BAD96466
BAD96473
BAG37332
CAD56658
EAW63156
EAW63157
|
|
|