InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXG1

Summary

InnateDB Protein

IDBP-4180.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXG1

Protein Name

forkhead box G1

Synonyms

BF1; BF2; FHKL3; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; FOXG1A; FOXG1B; FOXG1C; HBF-1; HBF-2; HBF-3; HBF-G2; HBF2; HFK1; HFK2; HFK3; KHL2; QIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000339004

InnateDB Gene

IDBG-4178 (FOXG1)

Protein Structure

UniProt Annotation

Function

Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. {ECO:0000269PubMed:12657635}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00089, ECO:0000269PubMed:21280142}.

Disease Associations

Rett syndrome congenital variant (RTTCV) [MIM:613454]: A severe neurodevelopmental disorder with features of classic Rett syndrome but earlier onset in the first months of life. Clinical features include progressive microcephaly, hypotonia, irresponsiveness and irritability in the neonatal period, mental retardation, psychomotor regression and stereotypical movements. {ECO:0000269PubMed:19578037, ECO:0000269PubMed:21280142}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expression is restricted to the neurons of the developing telencephalon. {ECO:0000269PubMed:7959731}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007420	brain development
GO:0007568	aging
GO:0045892	negative regulation of transcription, DNA-templated