Version 5.4
Mus musculus Protein: Cpped1
Summary
InnateDB Protein IDBP-401652.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cpped1
Protein Name calcineurin-like phosphoesterase domain containing 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000112587
InnateDB Gene IDBG-133470 (Cpped1)
Protein Structure
UniProt Annotation
Function Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004721 phosphoprotein phosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process
GO:0016311 dephosphorylation
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:2443300
InterPro IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like
PFAM PF00149
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BFS6
PhosphoSite PhosphoSite-Q8BFS6
TrEMBL
UniProt Splice Variant
Entrez Gene 223978
UniGene Mm.86360
RefSeq
MGI ID
MGI Symbol Cpped1
OMIM
CCDS
HPRD
IMGT
EMBL AK032288 AK041329 AK049721 AK080876 AK134718 BC025476 BC034347
GenPept AAH25476 AAH34347 BAC27795 BAC30908 BAC33892 BAC38056 BAE22255

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca