InnateDB Protein
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IDBP-376157.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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POLR2F
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Protein Name
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polymerase (RNA) II (DNA directed) polypeptide F
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Synonyms
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HRBP14.4; POLRF; RPABC14.4; RPABC2; RPB14.4; RPB6; RPC15;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000403852
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InnateDB Gene
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IDBG-7203 (POLR2F)
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Protein Structure
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Function |
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:9852112}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 162 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
162
[view]
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Protein-Protein |
20
[view]
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Protein-DNA |
142
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006110
RNA polymerase, subunit omega/K/RPB6
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PFAM |
PF01192
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P61218
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PhosphoSite |
PhosphoSite-P61218
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TrEMBL |
U3KQS8
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UniProt Splice Variant |
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Entrez Gene |
5435
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UniGene |
Hs.735742
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RefSeq |
NP_068809
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HUGO |
HGNC:9193
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OMIM |
604414
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CCDS |
CCDS13963
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HPRD |
05105
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IMGT |
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EMBL |
AF006501
AL031587
BC003582
CH471095
CR456546
CR457021
Z27113
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GenPept |
AAH03582
CAA81629
CAB62981
CAG30432
CAG33302
EAW60203
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