InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FECH

Summary

InnateDB Protein

IDBP-3745.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FECH

Protein Name

ferrochelatase

Synonyms

EPP; FCE;

Species

Homo sapiens

Ensembl Protein

ENSP00000262093

InnateDB Gene

IDBG-3741 (FECH)

Protein Structure

UniProt Annotation

Function

Catalyzes the ferrous insertion into protoporphyrin IX.

Subcellular Localization

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Disease Associations

Erythropoietic protoporphyria (EPP) [MIM:177000]: A form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. Erythropoietic protoporphyria is marked by excessive protoporphyrin in erythrocytes, plasma, liver and feces, and by widely varying photosensitive skin changes ranging from a burning or pruritic sensation to erythema, edema and wheals. {ECO:0000269PubMed:10942404, ECO:0000269PubMed:11375302, ECO:0000269PubMed:12063482, ECO:0000269PubMed:12601550, ECO:0000269PubMed:1376018, ECO:0000269PubMed:15286165, ECO:0000269PubMed:17196862, ECO:0000269PubMed:1755842, ECO:0000269PubMed:7910885, ECO:0000269PubMed:8757534, ECO:0000269PubMed:9585598, ECO:0000269PubMed:9740232}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004325	ferrochelatase activity
GO:0005515	protein binding
GO:0008198	ferrous iron binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006778	porphyrin-containing compound metabolic process
GO:0006783	heme biosynthetic process
GO:0009416	response to light stimulus
GO:0044281	small molecule metabolic process
GO:0046501	protoporphyrinogen IX metabolic process