InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FECH

Summary

InnateDB Protein

IDBP-3743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FECH

Protein Name

ferrochelatase

Synonyms

EPP; FCE;

Species

Homo sapiens

Ensembl Protein

ENSP00000372326

InnateDB Gene

IDBG-3741 (FECH)

Protein Structure

UniProt Annotation

Function

Catalyzes the ferrous insertion into protoporphyrin IX.

Subcellular Localization

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Disease Associations

Erythropoietic protoporphyria (EPP) [MIM:177000]: A form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. Erythropoietic protoporphyria is marked by excessive protoporphyrin in erythrocytes, plasma, liver and feces, and by widely varying photosensitive skin changes ranging from a burning or pruritic sensation to erythema, edema and wheals. {ECO:0000269PubMed:10942404, ECO:0000269PubMed:11375302, ECO:0000269PubMed:12063482, ECO:0000269PubMed:12601550, ECO:0000269PubMed:1376018, ECO:0000269PubMed:15286165, ECO:0000269PubMed:17196862, ECO:0000269PubMed:1755842, ECO:0000269PubMed:7910885, ECO:0000269PubMed:8757534, ECO:0000269PubMed:9585598, ECO:0000269PubMed:9740232}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004325	ferrochelatase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008198	ferrous iron binding
GO:0020037	heme binding
GO:0030350	iron-responsive element binding
GO:0046906	tetrapyrrole binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006778	porphyrin-containing compound metabolic process
GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006783	heme biosynthetic process
GO:0008203	cholesterol metabolic process
GO:0009416	response to light stimulus
GO:0009589	detection of UV
GO:0010038	response to metal ion
GO:0010288	response to lead ion
GO:0010468	regulation of gene expression
GO:0010999	regulation of eIF2 alpha phosphorylation by heme
GO:0017085	response to insecticide
GO:0030218	erythrocyte differentiation
GO:0034379	very-low-density lipoprotein particle assembly
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0046501	protoporphyrinogen IX metabolic process
GO:0046685	response to arsenic-containing substance
GO:0046984	regulation of hemoglobin biosynthetic process
GO:0051597	response to methylmercury
GO:0055072	iron ion homeostasis
GO:0070541	response to platinum ion
GO:0071549	cellular response to dexamethasone stimulus