InnateDB Protein
|
IDBP-373242.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
URGCP
|
Protein Name
|
upregulator of cell proliferation
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000396918
|
InnateDB Gene
|
IDBG-13865 (URGCP)
|
Protein Structure
|
|
Function |
May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer. {ECO:0000269PubMed:12082552, ECO:0000269PubMed:17217616}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:12082552, ECO:0000269PubMed:17217616}. Nucleus {ECO:0000269PubMed:12082552, ECO:0000269PubMed:17217616}. Note=In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.
|
Disease Associations |
|
Tissue Specificity |
Strongly expressed in hepatitis B virus- infected liver and in HCC cells. Also highly expressed in well- differentiated gastric cancer tissues and various gastric cancer cell lines. {ECO:0000269PubMed:12082552, ECO:0000269PubMed:17217616}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR006073
GTP binding domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
|
PFAM |
PF01926
|
PRINTS |
PR00326
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8TCY9
|
PhosphoSite |
PhosphoSite-Q8TCY9
|
TrEMBL |
C9JKA8
|
UniProt Splice Variant |
|
Entrez Gene |
55665
|
UniGene |
Hs.663312
|
RefSeq |
NP_001277005
|
HUGO |
HGNC:30890
|
OMIM |
610337
|
CCDS |
CCDS47578
|
HPRD |
11663
|
IMGT |
|
EMBL |
AB040940
AC004985
AK000661
AL833744
AY078404
BC018426
BX640797
CR749398
|
GenPept |
AAH18426
AAL83710
BAA91312
BAA96031
CAE45880
CAH18244
CAH56246
|
|
|