InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SDCBP

Summary

InnateDB Protein

IDBP-371091.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SDCBP

Protein Name

syndecan binding protein (syntenin)

Synonyms

MDA-9; MDA9; ST1; SYCL; TACIP18;

Species

Homo sapiens

Ensembl Protein

ENSP00000395351

InnateDB Gene

IDBG-22706 (SDCBP)

Protein Structure

UniProt Annotation

Function

Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. {ECO:0000269PubMed:10230395, ECO:0000269PubMed:11179419, ECO:0000269PubMed:11498591}.

Subcellular Localization

Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005109	frizzled binding
GO:0005137	interleukin-5 receptor binding
GO:0005515	protein binding
GO:0008093	cytoskeletal adaptor activity
GO:0042802	identical protein binding
GO:0045545	syndecan binding
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0006612	protein targeting to membrane
GO:0006930	substrate-dependent cell migration, cell extension
GO:0007268	synaptic transmission
GO:0007411	axon guidance
GO:0030036	actin cytoskeleton organization
GO:0035556	intracellular signal transduction
GO:0042327	positive regulation of phosphorylation
GO:0046330	positive regulation of JNK cascade

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005895	interleukin-5 receptor complex
GO:0005912	adherens junction
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle