InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DCC

Summary

InnateDB Protein

IDBP-369962.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCC

Protein Name

deleted in colorectal carcinoma

Synonyms

CRC18; CRCR1; IGDCC1; MRMV1; NTN1R1;

Species

Homo sapiens

Ensembl Protein

ENSP00000389140

InnateDB Gene

IDBG-3511 (DCC)

Protein Structure

UniProt Annotation

Function

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. {ECO:0000269PubMed:8187090, ECO:0000269PubMed:8861902}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Mirror movements 1 (MRMV1) [MIM:157600]: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. {ECO:0000269PubMed:20431009}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells. {ECO:0000269PubMed:7926722}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	53 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004888	transmembrane signaling receptor activity
GO:0005042	netrin receptor activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001764	neuron migration
GO:0001975	response to amphetamine
GO:0006915	apoptotic process
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0010976	positive regulation of neuron projection development
GO:0010977	negative regulation of neuron projection development
GO:0021965	spinal cord ventral commissure morphogenesis
GO:0033563	dorsal/ventral axon guidance
GO:0033564	anterior/posterior axon guidance
GO:0038007	netrin-activated signaling pathway
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0048671	negative regulation of collateral sprouting
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:2000171	negative regulation of dendrite development
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0032584	growth cone membrane
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR010560 Neogenin, C-terminal
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF06583
PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P43146