InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CXXC1

Summary

InnateDB Protein

IDBP-369744.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXXC1

Protein Name

CXXC finger protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000390475

InnateDB Gene

IDBG-3427 (CXXC1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269PubMed:21407193}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:12200428, ECO:0000269PubMed:17355966}. Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	41 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0045322	unmethylated CpG binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051568	histone H3-K4 methylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016363	nuclear matrix
GO:0016607	nuclear speck
GO:0035097	histone methyltransferase complex
GO:0048188	Set1C/COMPASS complex

Protein Structure and Domains

PDB ID

InterPro

IPR001965 Zinc finger, PHD-type
IPR002857 Zinc finger, CXXC-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
IPR022056 CpG binding protein, C-terminal

PFAM

PF02008
PF00628
PF12269

PRINTS

PIRSF

SMART

SM00249

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9P0U4