InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RECQL

Summary

InnateDB Protein

IDBP-369241.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RECQL

Protein Name

RecQ protein-like (DNA helicase Q1-like)

Synonyms

RecQ1; RECQL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000395449

InnateDB Gene

IDBG-22845 (RECQL)

Protein Structure

UniProt Annotation

Function

DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. {ECO:0000269PubMed:15886194, ECO:0000269PubMed:7961977, ECO:0000269PubMed:8056767}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:7961977}.

Disease Associations

Tissue Specificity

High expression in heart, lung, skeletal muscle and kidney, low expression in brain. {ECO:0000269PubMed:7961977}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	21 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0036310	annealing helicase activity
GO:0043140	ATP-dependent 3'-5' DNA helicase activity

Biological Process

GO:0000733	DNA strand renaturation
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR004589 DNA helicase, ATP-dependent, RecQ type
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR018982 RQC domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270
PF09382

PRINTS

PIRSF

SMART

SM00490
SM00487
SM00956

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P46063