InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STRAP

Summary

InnateDB Protein

IDBP-368431.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STRAP

Protein Name

serine/threonine kinase receptor associated protein

Synonyms

MAWD; PT-WD; UNRIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000392270

InnateDB Gene

IDBG-21633 (STRAP)

Protein Structure

UniProt Annotation

Function

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. {ECO:0000269PubMed:16251192, ECO:0000269PubMed:18984161}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	62 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000387	spliceosomal snRNP assembly
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010633	negative regulation of epithelial cell migration
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0016310	phosphorylation
GO:0030277	maintenance of gastrointestinal epithelium
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0032797	SMN complex
GO:0034719	SMN-Sm protein complex