InnateDB Protein
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IDBP-368204.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CELF4
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Protein Name
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CUGBP, Elav-like family member 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000410584
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InnateDB Gene
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IDBG-2659 (CELF4)
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Protein Structure
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Function |
RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. {ECO:0000269PubMed:11158314, ECO:0000269PubMed:12649496, ECO:0000269PubMed:14973222, ECO:0000269PubMed:15009664, ECO:0000269PubMed:15894795}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:14973222}. Cytoplasm {ECO:0000269PubMed:14973222}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Strongly expressed in the cerebellum, hippocampus, amygdala, temporal and frontal cortex and frontal lobes. {ECO:0000269PubMed:11158314, ECO:0000269PubMed:12438720, ECO:0000269PubMed:16862542}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0000380
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alternative mRNA splicing, via spliceosome
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GO:0000381
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regulation of alternative mRNA splicing, via spliceosome
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GO:0006376
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mRNA splice site selection
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GO:0007281
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germ cell development
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GO:0009790
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embryo development
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GO:0017148
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negative regulation of translation
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GO:0048026
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positive regulation of mRNA splicing, via spliceosome
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GO:0090394
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negative regulation of excitatory postsynaptic membrane potential
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BZC1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
K7EJK3
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UniProt Splice Variant |
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Entrez Gene |
56853
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UniGene |
Hs.602283
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RefSeq |
NP_064565
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HUGO |
HGNC:14015
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OMIM |
612679
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CCDS |
CCDS32818
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HPRD |
12534
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IMGT |
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EMBL |
AB209774
AC015961
AC090386
AC093332
AC129908
AF248650
AF248651
AF329265
AK074596
BC001946
BC004167
BC045711
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GenPept |
AAF86232
AAF86233
AAH01946
AAH04167
AAH45711
AAK07475
BAC11082
BAD93011
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