InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2E2

Summary

InnateDB Protein

IDBP-367614.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2E2

Protein Name

ubiquitin-conjugating enzyme E2E 2

Synonyms

UBCH8;

Species

Homo sapiens

Ensembl Protein

ENSP00000401053

InnateDB Gene

IDBG-22010 (UBE2E2)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. {ECO:0000269PubMed:20061386, ECO:0000269PubMed:20133869, ECO:0000269PubMed:9371400}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.

Experimentally validated
Total	81 [view]
Protein-Protein	81 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005524	ATP binding
GO:0042296	ISG15 ligase activity

Biological Process

GO:0032020	ISG15-protein conjugation
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination