Homo sapiens Protein: SATB1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-367089.4 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | SATB1 | ||||||||||||||||||||||
Protein Name | SATB homeobox 1 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000399708 | ||||||||||||||||||||||
InnateDB Gene | IDBG-21555 (SATB1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1- binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. {ECO:0000250, ECO:0000269PubMed:10595394, ECO:0000269PubMed:11463840, ECO:0000269PubMed:12374985, ECO:0000269PubMed:12692553, ECO:0000269PubMed:1505028, ECO:0000269PubMed:15618465, ECO:0000269PubMed:15713622, ECO:0000269PubMed:16377216, ECO:0000269PubMed:16630892, ECO:0000269PubMed:17173041, ECO:0000269PubMed:17376900, ECO:0000269PubMed:18337816, ECO:0000269PubMed:19103759, ECO:0000269PubMed:19247486, ECO:0000269PubMed:19332023, ECO:0000269PubMed:19430959, ECO:0000269PubMed:9111059, ECO:0000269PubMed:9548713}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus matrix. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs). | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed predominantly in thymus. {ECO:0000269PubMed:1505028}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR001356
Homeobox domain IPR003350 CUT domain IPR009057 Homeodomain-like IPR010982 Lambda repressor-like, DNA-binding domain |
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PFAM |
PF00046
PF02376 PF13413 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00389
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q01826 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q01826 | ||||||||||||||||||||||
TrEMBL | C9JP21 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 6304 | ||||||||||||||||||||||
UniGene | Hs.674678 | ||||||||||||||||||||||
RefSeq | NP_001124482 | ||||||||||||||||||||||
HUGO | HGNC:10541 | ||||||||||||||||||||||
OMIM | 602075 | ||||||||||||||||||||||
CCDS | CCDS2631 | ||||||||||||||||||||||
HPRD | 03647 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB209761 AC139618 AC144521 AK127242 BC001744 CH471055 M97287 | ||||||||||||||||||||||
GenPept | AAA60304 AAH01744 BAD92998 BAG54463 EAW64291 EAW64292 EAW64293 | ||||||||||||||||||||||