InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UNC5D

Summary

InnateDB Protein

IDBP-366565.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UNC5D

Protein Name

unc-5 homolog D (C. elegans)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000394303

InnateDB Gene

IDBG-16693 (UNC5D)

Protein Structure

UniProt Annotation

Function

Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007411	axon guidance

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000488 Death domain
IPR000884 Thrombospondin, type 1 repeat
IPR000906 ZU5 domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011029 Death-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF00531
PF00090
PF00791
PF07679
PF00047

PRINTS

PIRSF

SMART

SM00005
SM00209
SM00218
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6UXZ4