InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PAK6

Summary

InnateDB Protein

IDBP-365817.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAK6

Protein Name

p21 protein (Cdc42/Rac)-activated kinase 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000406873

InnateDB Gene

IDBG-6170 (PAK6)

Protein Structure

UniProt Annotation

Function

Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269PubMed:14573606, ECO:0000269PubMed:20054820}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.

Disease Associations

Tissue Specificity

Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. {ECO:0000269PubMed:11278661, ECO:0000269PubMed:11773441}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007010	cytoskeleton organization
GO:0023014	signal transduction by phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000095 CRIB domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00786
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00285
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt