InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCFD1

Summary

InnateDB Protein

IDBP-364980.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCFD1

Protein Name

sec1 family domain containing 1

Synonyms

C14orf163; RA410; SLY1; SLY1P; STXBP1L2;

Species

Homo sapiens

Ensembl Protein

ENSP00000390783

InnateDB Gene

IDBG-4265 (SCFD1)

Protein Structure

UniProt Annotation

Function

Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus, Golgi stack membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.

Experimentally validated
Total	42 [view]
Protein-Protein	41 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019905	syntaxin binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0001666	response to hypoxia
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0006892	post-Golgi vesicle-mediated transport
GO:0006904	vesicle docking involved in exocytosis
GO:0009636	response to toxic substance
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0060628	regulation of ER to Golgi vesicle-mediated transport

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005798	Golgi-associated vesicle
GO:0005801	cis-Golgi network
GO:0005886	plasma membrane
GO:0017119	Golgi transport complex
GO:0032580	Golgi cisterna membrane